Vitamin A inhibition of pancreatic cancer – Food Channel – People’s network

Vitamin A: inhibition of pancreatic cancer – Food Channel – People’s original title: vitamin A inhibit pancreatic cancer pancreatic cancer is a difficult diagnosis and treatment of gastrointestinal cancer. Researchers at the Imperial College London in the UK and Germany and the United States chose a new perspective to study the disease, focusing on the tumor cell population, the so-called stellate cells. They found that vitamin A may play an important role in inhibiting the spread of pancreatic cancer in the laboratory. Based on the relevant mechanisms, the medical profession may be able to find new ways to curb the spread of cancer. In a healthy pancreas, the stellate cells are in a resting state, storing large amounts of vitamin A and vitamin A. Vitamin A is usually converted to trans retinoic acid during metabolism, which plays an important role in growth, development and cell differentiation. With the development of pancreatic cancer, the tumor will be activated to send signals to the stellate cells, which will be released in vitamin A, vitamin A can not be metabolized in the stellate cells. Stellate cells activated form dense connective tissue around the tumor, the cancer cells with the help of these organizations spread to other parts of the body and connective tissue will also limit anticancer drugs directly to the tumor. The researchers stellate cells in the laboratory, the cause of vitamin A metabolism process, all trans retinoic acid produced by the surrounding environment can effectively prevent the stellate cell tumor, reduce the "transform" the formation of connective tissue, allowing the cancer cells not easily spread growth. The authors of the report, Anthony of the Imperial College London, said the study? Craunot Papadopoulos, not to destroy the stellate cells, but through special means to allow them to return to a dormant state, thereby reducing the connective tissue, reducing the tumor microenvironment, and ultimately inhibit cancer cell proliferation. The researchers also pointed out that they only observed the cells under specific conditions in the laboratory, there is no conclusive evidence to prove that mastering the use of vitamin A supplements for patients with pancreatic cancer was helpful, the future also need to include clinical trials, further research. (: Sheng, commissioning editor Quan Juan)相关的主题文章: